Clinical Pharmacokinetics of Rifampicin in Patients With
نویسندگان
چکیده
BIOCHEMICAL AND IMMUNOLOGICAL PARAMETERS 3 Medellín-Garibay SE1, Cortez-Espinosa N1, Milán-Segovia RC1, Magaña-Aquino M2, 4 Vargas-Morales JM1, González-Amaro R3, Portales-Pérez DP1, Romano-Moreno S1#. 5 1Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis 6 Potosí, México; 2Hospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí, 7 México; 3Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis 8 Potosí, México. 9 10 Running title: Effect of Diabetes on Rifampicin Pharmacokinetics 11 12
منابع مشابه
A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses.
Accumulating evidence suggests that increasing doses of rifampicin may shorten tuberculosis treatment. The PanACEA HIGHRIF1 trial assessed safety, pharmacokinetics, and antimycobacterial activity of rifampicin at doses up to 40 mg/kg. Eighty-three pulmonary tuberculosis patients received 10, 20, 25, 30, 35, or 40 mg/kg rifampicin daily over 2 weeks, supplemented with standard doses of isoniazid...
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متن کاملPharmacokinetic interactions between efavirenz and rifampicin in HIV-infected patients with tuberculosis.
OBJECTIVE To evaluate the pharmacokinetic interactions between efavirenz and rifampicin (rifampin) in patients with HIV infection and tuberculosis. DESIGN Nonblind, randomised, pharmacokinetic study. PATIENTS 24 patients (21 male, 3 female; mean age 37 years) with HIV infection and tuberculosis. INTERVENTIONS Patients were randomised to one of the following treatments: group A (n = 16) re...
متن کاملDevelopment of a single-tube, low-cost, analytical process to extract, separate and determine efavirenz and rifampicin plasma concentrations in HIV/TB co-infected patients
Background Tuberculosis (TB) complicating HIV-1 infection is a persistent significant clinical concern, particularly in resource limited settings. Treatment of HIV-infected patients with TB often comprises efavirenz-containing antiretroviral regimens particularly when on TB treatment containing rifampicin. Although rifampicin may reduce EFV concentrations, little is known of the effect of the H...
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Acocella, G. (1978). Clinical pharmacokinetics of rifampicin. Clin. Pharmacokin., 3, 108-127. Binda, G., Domenichini, E., Gottardi, A., Orlandi, B., Ortelli, E., Pacini, B. & Fowst, G. (1971). Rifampicin, a general review. Arzneim-Forsch., 21, 1907-1977. Conney, A. H. (1967). Pharmacological implications of microsomal induction. Pharmac. Rev., 19, 317366. Das, K. M. & Dubin, R. (1976). Clinical...
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